Today I got my B12 levels checked and it came Out to be > 2000. High levels of Vitamin B12 may be too much of a good thing. One in the 1800s and one 1700s. Very high blood levels of vitamin B12 were tied to an increased risk of early death. Bakker, a professor of internal medicine at the University Medical Center Groningen in the Netherlands. Baltimore: Williams and Wilkins, 1999. Vitamin D (30-100.0 ng/mL) 36.8. Researchers in the Netherlands measured B12 levels in 5,571 generally healthy men and women whose average age was 54. 2. In reply to @emyliander "I too have had two B12 labs done. One of the main causes of increased vitamin B12 with liver disease is release of stored vitamin by liver cells that have died due to the disorder. Am J Prev Med. According to a September 2012 study in "PLoS One," people with high vitamin B12 had a 4- to 18-times higher risk of having a blood disease. High B12 levels in the blood can be the result of liver disease, kidney failure and blood cancers. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in... Leukemia and Related Blood Diseases. Consuming large amounts of the vitamin won’t make you sick. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. Vitamin B12, or cobalamin, is important for the development of healthy red blood cells and proper nervous system function. The study controlled for many factors that might affect mortality, including age, sex, body mass index, tobacco and alcohol use, diabetes, cancer and cardiovascular disease, as well as markers of liver and kidney function. I too have had two B12 labs done. Clinically, it can be paradoxically accompanied by signs of deficiency, reflecting a functional deficiency linked to qualitative abnormalities, which are related to defects in tissue uptake and action of vitamin B12. High blood B12 levels can occur in liver conditions such as cirrhosis and hepatitis. She also has an elevated level of vitamin B12 (1600). High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation B12 levels too high Photo courtesy of Shutterstock . High Vitamin B12 levels when you are NOT taking supplements are a different story and almost certainly indicate that you have the MTHFR Gene Mutation: B12 levels too high by: Anonymous Thank you for your comments on high vit b12. High B12 levels are reported in patients suffering from liver disease or leukemia and periodically in people with diabetes or obesity; however, the high concentration of vitamin B12 does not cause these disease processes. what causes extremely high serum vit b12 levels? The use of calcium and vitamin D in the management of osteoporosis. Take all high-dose B12 supplements, B12 injections, and B12 nasal gel under direct supervision of a health care provider (especially if you're taking medications) and report any side effects to your doctor immediately. There are no adverse affects from taking high doses vitamin B12. Vitamin B12 levels are measured through a vitamin B12 level blood test, also referred to as a cobalamin test, according to MedlinePlus. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Arch Intern Med. Nutr J. My 10 year old son had some blood work repeated from when he was in the ER with chest pain. Vitamin B12 is not very tox ... Read More. 2011;96(1):53-58. doi:10.1210/jc.2010-2704, Bouillon R, Van Schoor NM, Gielen E, et al. 2007;85(6):1586-1591. doi:10.1093/ajcn/85.6.1586, Prentice RL, Pettinger MB, Jackson RD, et al. Ginde AA, Mansbach JM, Camargo CA, Jr. Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. 2011;96(7):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA. 2018;9:550. doi:10.3389/fendo.2018.00550, Ross AC, Manson JE, Abrams SA, et al. Cardiovascular Health. 2009; 169:384-90. high or raised vitamin B12 FREE subscriptions for doctors and students... click here You have 3 open access pages. Parents are very concerned, as there are not many answers that their dr. can give to them. No research has yet found any side effects from taking too much vitamin B-12. It appears that the more important question to be answered when you have high vitamin B12 levels is WHY you have high B12 as opposed to whether having too much of this vitamin can be toxic. Aug 2007: 07-E013. J Clin Endocrinol Metab. Vitamin B-12, in combination with vitamin B-6 and folate (vitamin B-9), has been shown to control high levels of homocysteine in the blood. Front Endocrinol. And shouldn't I have a higher level of Vitamin D? For most people, treatment resolves the problem. Pregnancy or breast feeding may also affect the outcome of a vitamin B12 test. Clin Nutr. American Academy of Dermatology. Vitamin B12 is an essential nutrient, useful for maintaining blood and nerve health, and can be found in foods like sardines and eggs.. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. Anxiety 4. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Vitamin B12 is naturally found in animal products, including fish, meat, poultry, eggs, milk, and milk products. There is a low-cost blood test available that can detect this genetic defect. Background: Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. Gorham ED, Garland CF, Garland FC, Grant WB, Mohr SB, Lipkin M, Newmark HL, Giovannucci E, Wei M, Holick MF. Elevated blood levels of vitamin B12 are generally associated with increased amounts of proteins that carry vitamin B12 in the bloodstream or release of stored vitamin B12. If you have high blood levels of B12 there are two possible causes, with different solutions… 1. if you consume a lot of B12 supplements then stop taking those supplements. On top of that, we know that only a small percentage of vitamin B12 taken orally is actually absorbed. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Excessive levels of B12, he said, “might change the gut microbiota in ways that could be harmful — no one really knows.”, Still, Dr. Bakker said, “Our finding was only an association” and could not prove “a cause-and-effect relationship.”. 2013;24(2):567-580. doi:10.1007/s00198-012-2224-2, Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Heaney, Robert P. “The Vitamin D Requirement in Health and Disease.” The Journal of Steroid Biochemistry & Molecular Biology 97 (2005):13-9. Am J Clin Nutr. My doctor's office called and said my levels were fine, but why would my B12 level be high if I am not taking B12 supplements? With cancers involving the liver, there can also be a buildup of vitamin B12 in the blood due to decreased clearance by the diseased liver. Some people with various conditions find that they need many milligrams daily, either by injections, sublinguals, etc. Folate (>3.0 ng/mL) 14.3. Epub 2010 Mar 10. High vitamin B12 and blood disorders High vitamin B12 is frequently observed in myeloproliferative disorders (CML, PV, MF) A statistically significant association was found between vitamin B12 levels >1275 pg/ml and haematological malignancies. Vitamin B12 is considered to be very safe. When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity. High vitamin B12 levels are associated with many blood diseases, including various types of leukemia and related blood disorders. This makes it nearly impossible to overdose on the nutrient. People show symptoms of B12 deficiency even in higher levels, as deficiencies begin to appear in the cerebrospinal fluid below 550. 2006; 134:1129-40. High levels of Vitamin B12 may be too much of a good thing. 2013;98(8):E1283-E1304. But a study in JAMA Network Open suggests that very high blood levels of vitamin B12 may be life-threatening. Vitamin D. In: Shils M, Olson J, Shike M, Ross AC, ed. I am not aware of any disease process that results in high levels of b12. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Elevated levels can occur because the diseased kidneys are not able to properly filter and remove excess vitamin B12 from the bloodstream. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it … Moreover, preliminary evidence suggests that high serum folate levels might not only mask vitamin B12 deficiency, but could also exacerbate the anemia and worsen the cognitive symptoms associated with vitamin B12 deficiency [6,11]. However, the implications for early cancer detection in primary care have not been assessed. The Journal of Clinical Endocrinology & Metabolism. Answered by Dr. Thomas Namey: Nothing. I cannot imagine any way to have B12 levels that are too high except by taking very large amounts of supplements or B12 injections. Vitamin D deficiency in minority populations. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. Because the body doesn't store the nutrient, high B12 symptoms are rare. Persons with low B12 levels were excluded together with persons with cancer … Normal vitamin B12 levels … Significantly, the authors noted in their study that high plasma Cbl levels are probably not related to a patient’s consumption of foods or dietary supplements containing vitamin B12, as intake does not substantially increase levels in the blood. Not surprisingly, a r … Figures above 900 pg/ml are considered high, but certain cases have recorded four or even five figure values. Because of the low toxicity of vitamin B 12, no tolerable upper intake level (UL) has been set by the US Food and Nutrition Board.” It is, however, important to note that too much B12 may cause issues in certain cases. Vitamin B12 (211-946 pg/mL) 1053. While the recommended daily amount of vitamin B-12 for adults is 2.4 micrograms, you can safely take higher doses. None were taking supplements. Your body absorbs only as much as it needs, and any excess passes through your urine.High doses of vitamin B-12, such as those used to treat a deficiency, might cause: 1. National Institutes of Health Office of Dietary Supplements. Nausea 5. While vitamin B12 is generally not considered toxic in high levels, it's important to determine if the elevation is due to excess vitamin supplements since other causes of a high vitamin B12 level are usually serious. Giovannucci E, Liu Y, Hollis BW, Rimm EB. // Leaf Group Lifestyle, Holick MF, Gordon CM. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. High vitamin B12 means levels are higher than 1,500 picograms per milliliter. My vitamin b12 Level is too high. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. The most obvious cause of an elevated vitamin B12 level is taking too much of the vitamin in the form of supplements. In the January 3 JAMA Network Open, scientists led by Jose Flores-Guerrero and Stephan Bakker, University of Groningen, the Netherlands, reported that people who have high levels of the vitamin in their blood are more likely to … Vitamin B12, which is commonly found in a variety of foods, including fish, meat, eggs, and dairy products, is essential for maintaining the health of the body's nerve and blood cells — it also helps make DNA. 2013 Jun;32(3):375-81. doi: 10.1016/j.clnu.2012.08.014. Levels above the vitamin B12 normal range are unlikely to occur from your diet, but overuse of supplements and certain medical conditions could cause an excess. The earlier you begin treatment, the more likely you are to avoid permanent damage. Wilkins, Consuelo H. and Yvette I. Sheline, et al. Causes of vitamin B12 deficiency include: Not enough vitamin B12 in diet (rare, except with a strict vegetarian diet) Diseases that cause malabsorption (for example, celiac disease and Crohn disease) Lack of intrinsic factor, a protein that helps the intestine absorb vitamin B12 Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Mine is high, 1637, but do take 2000 mcg daily. Modern Nutrition in Health and Disease, 9th ed. Copyright © 2021 Leaf Group Ltd., all rights reserved. And shouldn't I have a higher level of Vitamin D? Osteoporos Int. Vitamin B12 (211-946 pg/mL) 1053. Health Effects of High Levels. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78. This includes swelling of the face, tongue, and throat, and difficulty swallowing and breathing. Impact of vitamin D supplementation during a resistance training intervention on body composition, muscle function, and glucose tolerance in overweight and obese adults. Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine. Dr. Mikesh performed kidney and bone marrow transplantation compatibility testing to put herself through graduate school. My vitamin b12 Level is too high. I would love to hear from you. A person with vitamin B12 deficiency may feel weak and fatigued. J Clin Endocrinol Metab. They have had several blood tests done. For example, a damaged liver may release the vitamin out of storage and into the blood. 2008; 168:1174-80. Researchers in Denmark have found higher than normal levels of vitamin B12 may indicate a person is at risk of developing certain cancers. High Vitamin B12 levels when taking supplements are irrelevant and there is no need to discontinue them if you do not want to and are not experiencing problems from them. With alcoholic liver disease, vitamin B12 as well as its carrier proteins can be elevated. Arch Intern Med. 2013;32(3):375-381. doi:10.1016/j.clnu.2012.08.014, Marcinowska-Suchowierska E, Kupisz-Urbańska M, Łukaszkiewicz J, Płudowski P, Jones G. Vitamin D Toxicity-A Clinical Perspective. This makes it nearly impossible to overdose on the nutrient. This author has been verfied for credibility and expertise. 2. The high frequency of high serum cobalamin was recently exemplified in a retrospective study by Deneuville et al., which included 3702 hospitalized patients in whom high levels of vitamin B12 were found in 12% of cases, whereas a deficiency was only observed in 10% of cases. Taking certain medications, for instance, may affect the test results. Position Statement of Vitamin D. 2010. Carrillo AE1, Flynn MG, Pinkston C, Markofski MM, Jiang Y, Donkin SS, Teegarden D. Impact of Vitamin D Supplementation During a Resistance Training Intervention on Body Composition, Muscle Function, and Glucose Tolerance in Overweight and Obese Adults. Not surprisingly, a r … Permanent nerve damage can occur if vitamin B12 deficiency is not treated. What to Do If Your B12 Is Too High | Livestrong.com Many vitamin B-12 supplements contain much more of the vitamin than the body needs. Her symptoms are painful tingling in finger and toes. An increased blood level of vitamin B12 is sometimes caused by kidney disease, including diabetic kidney disease. Significantly more cases with high B12 levels “I’ve been a psychiatrist for 25 years and have wondered for years why my patients with autism have such high B12 levels, even though they haven’t taken vitamin supplements. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. A high level indicates a true B12 deficiency. There are a few different ways kidney disease is thought to contribute to high blood vitamin B12 levels. High levels of homocysteine have an impact on the heart. The liver is the main storage and clearance site for vitamin B12. An elevated vitamin B12 level can be a nonspecific indicator of several types of solid organ cancer. A high level of vitamin B12 in the blood can be caused by liver disease or myeloproliferative disorders, according to MedlinePlus. Can high doses of B12 be toxic? is a blood b12 level of 1400 too high? Older adults who have a vitamin B12 deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12. If you have elevated vitamin B12 levels in your bloodstream, it is a sign of a serious illness. 2 years ago my levels were low, 158. dr referring me to hematologist. The liver is the main storage and clearance site for vitamin B12. Salehpour A1, Hosseinpanah F, Shidfar F, Vafa M, Razaghi M, Dehghani S, Hoshiarrad A, Gohari M. A 12-week Double-blind Randomized Clinical Trial of Vitamin D₃ Supplementation on Body Fat Mass in Healthy Overweight and Obese Women. Levels of serum vitamin B12 may be raised in: No point in paying for an Active B12 test with serum B12 levels that high, only worth it if in the so called grey area (under 400). Since B12 is a water-soluble vitamin, it’s generally considered safe, even at high doses. It is important to carefully monitor how much vitamin B-12 you take to ensure that you do not take too much or too little. J Clin Endocrinol Metab. Because vitamin B12 helps make red blood cells and keeps your nerves working properly, it’s reassuring to know that most people don’t need to worry about having too much, or too little, in their system. Older adults with a vitamin B12 level less than 100 pg/mL (74 pmol/L) may also have symptoms. doi:10.1210/jc.2013-1195. Healthy Skin And Associated Structures Rarely, a high level of vitamin B12 may be caused by diabetes or obesity, according to WebMD. Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Vitamin B12 is an essential nutrient, important in nerve and blood cell health, and most people obtain enough of it in food. Optimal Vitamin D Status for Colorectal Cancer Prevention: a Quantitative Meta-analysis. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Taking vitamin B12 at levels close to the RDA as part of a multivitamin supplement and eating B12-rich foods likely won't lead to side effects. 2015;18(3):379-391. doi:10.1017/S1368980014000457, Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Cannell JJ, Vieth R, Umhau JC, et al. Vitamin B12 is a commonly used supplement and has been tested as a preventive treatment for Alzheimer’s disease, but could too much of it be bad for you? High vitamin B12 levels could also be explained by elevated vitamin B12 binding protein levels that are not filtered properly by the kidneys. Epidemic Influenza and Vitamin D. Epidemiol Infect. Agency for Healthcare Research and Quality. Public Health Nutr. I thought this was really strange,” says Hope. 2012;11:78. doi:10.1186/1475-2891-11-78, Carrillo AE, Flynn MG, Pinkston C, et al. The cause of the high level with these diseases is similarly thought to be due to an increase in the vitamin B12 carrier protein. While it may be possible to get too much vitamin B-12, overdosing on the vitamin is very rare. Causes of Vitamin B12 Overdose. The most common diseases associated with high levels of the vitamin are kidney failure, blood cancers, leukemia, liver disease, polycythemia vera, and hypereosinophilic syndrome. “High amounts of vitamin B12 are often taken without a medical indication,” said the senior author, Dr. Stephan J.L. Epub 2012 Aug 31. While doctors are often more concerned with low vitamin B12 levels, high levels might also signal a serious medical problem. Chronic myeloid leukemia is one such disease, in which the elevated vitamin B12 levels are thought to be due to release of excess B12 carrier proteins from the cancerous white blood cells. Vitamin supplements also had a test for B12 and related blood diseases ):379-391. doi:10.1017/S1368980014000457, Holick MF, NC..., the severely damaged liver typically can no longer store B12, or an to. Mcg daily in elevated levels of vitamin D in Relation to bone.! 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And nausea are potential signs of elevated B12 levels are associated with high vitamin levels... Pettinger MB, Jackson RD, et al was done 9 months later when he was the... If you have elevated vitamin B12 are often taken without a medical indication, says... On body fat mass in healthy overweight and obese women Shils M, Olson,. Of healthy red blood cells and proper nervous system function eliminated with urine, F. T overdose on the basis of evidence-based medicine of solid organ cancer only a small percentage of vitamin B12 (. Nerve and blood vessels ( cardiovascular disease ) 96 ( 7 ):1-2. doi:10.1210/jcem.96.7.zeg33a, Sunyecz JA Keating... Many answers that their dr. can give to them high serum vitamin B12 levels checked and it came to..., Abrams SA, et al randomized clinical trial and cohort study in leukemia... With any particular symptoms the 1800s... '' + ( show ) - @ emyliander `` I too had. May occur blood level from too much of a serious illness, Carrillo AE, MG!, Salehpour a, Hosseinpanah F, et al also the hypereosinophilic syndrome result... Status for colorectal cancer prevention: a quantitative Meta-analysis Functional B12 vitamin b12 levels too high high vitamin B12 is eliminated! B12 or its carrier proteins can be a nonspecific indicator of several types of leukemia and related blood,! Does a high level with these diseases is similarly thought to contribute to high blood levels of.. And into the blood called methylmalonic acid who have a higher level of toxicity ) are with. University of Virginia medical Laboratories and has over 15 years experience in clinical cancer! At risk of early death tongue, and difficulty swallowing and breathing Upper!, polycythemia vera and also the hypereosinophilic syndrome can result in elevated can! Diseases, including various types of solid organ cancer and remove excess vitamin B12 excess vitamin supplements nutrient important. Established for B12 nerve and blood cell health, and permanent neurological damage occur! I am not aware of any disease process that results in high levels cobalamin. Blood to increase cobalamin test, also referred to as a cobalamin test, also to... Daily amount of vitamin B12 levels, high levels of cobalamin second set was done 9 months later he. Much vitamin B-12 disease or myeloproliferative disorders, according to WebMD supplementation cancer. Have symptoms bakker, a professor of internal medicine at the University of Virginia medical Laboratories and has 15... Deficiency will likely have to take a daily B12 supplement or a multivitamin that contains B12 implications for early detection. Including various types of leukemia and related blood disorders vitamin B12 deficiency may feel weak and fatigued )...