Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. The Kruskal-Wallis test was done to check median differences between the independent groups. A total of 177 different authors contributed to the list of top-cited articles. Wood & Myers, oral & maxillofacial surgeons, serve the Harrisburg, Lancaster & Philadelphia area. However, a statistically significant trend () was observed between the impact factor of the journal and the number of “classics” published in that journal. First, for a particular research area, many factors may affect the citation count, including article age, journal of publication, author’s reputation, institution, and country of origin as well as the original language. However, the optimal coating methodology has not been clarified. Furthermore, for corresponding authors working in multiple institutions, we only considered the first institution. Audience should aim beyond the impact factor and evaluate scientific publications individually. A value of was considered statistically significant. However, the role of BMP9 in promoting the odontogenic differentiation of DPCs and dentinogenesis is worth to know. Post hoc testing was used to evaluate the median differences within each group. A total of 182 keywords were identified (Figure 5). Bone morphogenetic proteinsand the induction of periodontal tissue regeneration INDIAN DENTAL ACADEMY Leader in Continuing Dental Education www.indiandentalacademy.com 2. Die BMPs werden auch als parakrine Signalmoleküle bezeichnet. 2 0 obj % PdfSharp.Pdf.PdfDictionary Scientists, funding agencies, and research organizations necessitate metrics to determine the impact of research. Several bibliometric studies have reported that authors hailing from institutions of Asia and Africa whether being the first or the corresponding authors made an almost negligible contribution which could be regarded as the “classic article” [76, 83, 88, 90, 91]. In the current study, we used the rat model to explore the potential antifibrotic role of BMP-7 and its underlying mechanism in silica-induced pulmonary fibrosis. Dentists using this procedure have noted more bone growth in the four weeks after implantation than with traditional grafting procedures. DBM is the most widely used form of allograft in restoring bone defects in dentistry and orthopedics. , 1986 ; Masuda, Fukabori, Nakano, Shimizu, & Yamanaka, 2004 ). For example, the citation range of articles varied from 81 to 557 (WoS) and 95 to 1080 (Google Scholar). Furthermore, the European countries such as Austria, Germany, Italy, Netherlands, Switzerland, and the UK, despite their small population, as compared with the US and Asian countries, made considerable contributions (28%). %PDF-1.4 Sign up here as a reviewer to help fast-track new submissions. Many articles on bone morphogenetic proteins (BMPs) have been published. Many articles on bone morphogenetic proteins (BMPs) have been published. Progress in understanding the role of bone morphogenetic proteins (BMPs) in craniofacial and tooth development, the demonstration of stem cells in dental pulp and accumulating knowledge on biomaterial scaffolds have set the stage for tissue engineering and regenerative therapy of the craniofacial complex. During surgery, the BMP is soaked onto and binds with a collagen sponge. During surgery, the BMP is soaked onto and binds with a collagen sponge. In-vitro studies have shown that rhBMP-2 can increase the proliferation of several multipotent cell lines, which can differentiate into osteoblasts, or bone-forming cells.3-7 As the inducers of ectopic bone formation, bone morphogenetic proteins (BMPs) were first discovered by the American orthopedic surgeon Marshall R. Urist, who reported his results in the semen samples [1]. Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in extracts derived from bone, are now known to play important roles in a wide array of processes during formation and maintenance of various organs including bone, cartilage, muscle, kidney, and … Bibliometric analysis is helpful to determine the most influential studies in a specific field. Using your body’s existing healing channels is the best way to promote healing and growth, and the FDA has approved BMP is useful for a variety of oral surgery procedures. /Type /Font Supplementary 2. This reflects the influence and quality of an article’s topic along with its relevance to the clinical practice and research. Bone-derived BMPs, with a collagenous matrix as carrier, induced cementum and alveolar bone regeneration in surgically created furcation defects in the primate. An interesting finding of this analysis is that 22% of the most-cited articles were written by authors hailing from Asia (Japan and South Korea) and Africa (South Korea). >> This is a genetically engineered version of a protein that is normally found in the body. The distribution of data regarding citation count, citation density, and article age were not normal (Shapiro-Wilk test; ). Of 1341 publications, the top 50 were included based on their citation count. Implantation of bone morphogenetic protein, recently approved by the Food and Drug Administration, is a new way to facilitate bone growth around the jaw. Journals’ impact factors ranged from 0.785 (Journal of Craniofacial Surgery) to 5.125 (Journal of Dental Research). There is no study to investigate BMP-7's role in the development of pulmonary fibrosis induced by silica. With their introduction, tissue engineering, a relatively new field of reconstructive biology that utilizes mechanical, cellular, and biologic mediators to facilitate reconstruction/regeneration of a particular tissue, is being introduced to dentistry. The sponge is then designed to resorb, or disappear, over time. , 1992 ; Feeley, Krenek et al. Die knochenmorphogenetischen Proteine (englisch bone morphogenetic proteins, BMPs) sind eine Gruppe einander ähnlicher Signalproteine, die von Tierzellen ausgeschüttet werden, um benachbarte Zellen zu beeinflussen, so genannte Zytokine. Bone morphogenetic protein works because it mimics the exact structure of the molecules that support bone growth in your body. Network analysis of keywords. An electronic search was conducted using the Web of Science (WoS) “All Databases” … Most of the publications were animal studies () and focused on BMP-2 (). Bone morphogenetic protein 9 (BMP9) is one of the most effective BMPs to induce the differentiation tem cells. Elsevier’s Scopus, Google Scholar, and the Clarivate Analytics’ WoS may differ quantitatively or qualitatively regarding the citation count of a research article depending upon its research area [47, 66, 67], journals [68], and year of publication [69]. A recent and revolutionary invent, rhBMP-2 (recombinant human Bone Morphogenetic Protein), is successfully used to treat jaw bone defects at Balaji Dental and Craniofacial Hospital. According to the hierarchy of evidence levels (ELs), most of the top cited articles were within evidence level V (), followed by EL III (), EL II () and EL IV (). Association of (a) citation count with age of publication and (b) citation density with age of publication. Though BMP-mediated fracture healing has been well-documented in preclinical models, there has been no clinical study that demonstrated unequivocally … Simple linear regression analysis of different journal metrics. They are also known to be involved in chondrogenesis and osteogenesis, and they play a vital role in fracture healing and embryonic development [9–12]. Furthermore, it is a fact that some authors may be inclined to cite the articles from a specific journal in which they intend to publish an article [115]. A statistically nonsignificant trend () was observed between a journal age and the number of “classic” articles published in that journal. The year of publication has an undeniable influence on citation a publication would receive. Its citation density is 17.40, with a CCI of 11. Bone morphogenic proteins (BMPs) are a group of osteoinductive proteins obtained from nonmineralized bone matrix; they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hence, publications regarding stem cells (927-14,575) [72], cardiology (331-3484) [73], head and neck oncology (628-3205) [74], and respirology (615-2918) [75] are more often cited than publications within dentistry (326-2050) [44], despite all these areas having equal scientific significance. Bone Morphogenetic Protein Miracle protein BMP transforms cleft surgery at Balaji Dental & Craniofacial Hospital. Recombinant human BMP‐2 (rhBMP‐2), for example, has been shown to induce ectopic bone formation in an in vivo setting. Abstract- Bone Morphogenetic Proteins which are part of extracellular matrix are capable of inducing de novo bone formation. In order to screen out the most important independent variables, simple linear regression was performed. The osteoinductive functions are displayed by only a small number of BMPs, such as BMP-2, BMP-4, BMP-6, BMP-7, and BMP-14 [11, 13–17], leading to the suggestion that they should be renamed as Body Morphogenetic Proteins. has the highest score [58]. To prevent daily updating bias, a comprehensive search was performed on a single day, the 1st of March 2020. Publication title, authorship, citation count (extracted from WoS and Google Scholar), Current Citation Index (CCI) 2019 (citation received in the preceding year of conducting the study) [54], citation density (citation per annum) [55], year of publication, country and institution of origin, journal of publication, type of BMP, study design and evidence level of publication, and keywords were extracted and analyzed for each selected article. This bibliometric analysis is aimed at identifying and analyzing the top 50 most-cited articles on the dental applications of BMPs. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone.During surgery, the BMP is soaked onto and binds with a collagen sponge. Review articles are excluded from this waiver policy. Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Bone Morphogenetic Protein. Its calculation is based on the citation counts of items published in the past 5 years in the JCR per annum. During surgery, the BMP is soaked onto and binds with a collagen sponge. In oral and maxillofacial surgery, BMPs are used for alveolar bone regeneration [8, 13–15, 17, 30, 58], sinus lift augmentation [3, 5, 31, 61, 113], dental implants [16, 32], and periodontal [33–37] and dental regeneration [24–29]. The Visualization of Similarities viewer (VOSviewer) software [57] was used to create collaboration network maps regarding the cooccurrences of all keywords. Recent advances in molecular biology of the bone morphogenetic proteins (BMPs) have set the stage for tissue engineering of bone and related tissues, including the periodontium. Request a consult or call 717-763-1970 for more information. Usually, authors target journals with the highest impact factor instead of journals having the best readers for their article [99]. /Rect [50.59 713.69 168.77 721.66] The remaining bibliometrics are less well-known as predictors of citations; for instance, the number of publications at least scales with a journal size; however, it does not consider quality; this left the ES as a victor in an unbalanced contest [99]. The most productive year in terms of publications was 1997 (), followed by 2000 and 2005, with 6 publications each. /Subtype /Link The key steps in this cascade are chemotaxis, mitosis, and differentiation. << Bone Morphogenetic Protein (BMP2-Infuse) Bone morphogenic protein is a revolutionary growth factor that induces stem cells in our body to form new bone. Compre o livro Present Status of Bone Morphogenetic Proteins in Dentistry na Amazon.com.br: confira as ofertas para livros em inglês e importados Concerning the evolution of scientific production, few dental specialties including Periodontology [50] or Implantology [78] have undergone a hike in the quantity of research published in recent years. The present study presents insights into the past and recent trends in the applications of BMPs in dentistry. Bone Morphogenetic Protein. A statistical bias may occur once the address of the corresponding author is changed [116]. Its calculation follows the following formula: citations from journal citation report (JCR) year of documents published in the last 5 years, divided by the total number of citable documents [56]. For example, the 2nd position in Supplementary Table 1 is achieved by a paper that was published in 2005 [58], securing 270 citations within only 14 years. Most of the articles were within evidence level V (). /Border [0 0 0] In the present study, majority of the studies (58%) were published in high impact factor journals dedicated to dentistry, oral surgery, and medicine such as the Journal of Periodontology, Journal of Dental Research, Journal of Clinical Periodontology, and Clinical Oral Implants Research. Though BMP-mediated fracture healing has been well-documented in preclinical models, there has been no clinical study that demonstrated unequivocally … Bone morphogenetic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. Jain AP, Pundir S, Sharma A. The true influence of a research article can be determined properly at least 20 years after its publication [44, 65, 76]. A Demineralized Bone Matrix (DBM) is a variety of allograft obtained from cadavers. %���� Similarly, the 3rd and 4th positions are achieved by articles that were published in 2004 [59] and 2005 [61], securing 261 and 253 citations, respectively. A lack of association indicates that high-quality research might be highly cited, even if it is published in a relatively low impact factor journal [97, 98]. invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004,”, J. D. Schwender, L. T. Holly, D. P. Rouben, and K. T. Foley, “Minimally invasive transforaminal lumbar interbody fusion (TLIF),”, D. S. Baskin, P. Ryan, V. Sonntag, R. Westmark, and M. A. Widmayer, “A prospective, randomized, controlled cervical fusion study using recombinant human bone morphogenetic protein-2 with the CORNERSTONE-SR™ allograft ring and the ATLANTIS™ anterior cervical plate,”, S. D. Glassman, L. Carreon, M. Djurasovic et al., “Posterolateral lumbar spine fusion with INFUSE bone graft,”, K. Singh, J. D. Smucker, S. Gill, and S. D. Boden, “Use of recombinant human bone morphogenetic protein-2 as an adjunct in posterolateral lumbar spine fusion,”, M. F. Swiontkowski, H. T. Aro, S. Donell et al., “Recombinant human bone morphogenetic protein-2 in open tibial fractures,”, A. L. Jones, R. W. Bucholz, M. J. Bosse et al., “Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects,”, S. Govender, C. Csimma, H. K. Genant et al., “Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures,”, N. Schwartz and B. Hicks, “Segmental bone defects treated using recombinant human bone morphogenetic protein,”, P. J. Boyne, R. E. Marx, M. Nevins et al., “A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation,”, W. F. McKay, S. M. Peckham, and J. M. Badura, “A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE® Bone Graft),”, X. Zhao, L. Guo, Y. Lin et al., “The top 100 most cited scientific reports focused on diabetes research,”, Y. Zhang, J. Huang, and L. Du, “The top-cited systematic reviews/meta-analyses in tuberculosis research: a PRISMA-compliant systematic literature review and bibliometric analysis,”. These are exciting times in the field of BMPs, and their potent osteoinductive properties place them on the threshold of clinical applications in dentistry. In general, when a scientific article makes its appearance on the list of most frequently cited articles in its respective discipline, it shows that it has reached a landmark [46]. (1)Five-year journal impact factor: this indicator represents the citation counts received by a journal, in one year, of the citable papers published in the last 5 years. 9, SEPT 2003 Presented by:- ROSHNI MAURYA 2. While recombinant human BMP-2 (rhBMP-2) has been commercially available in cases of non-union fracture and spinal fusion in orthopaedics, it has also been applied to improve bone regeneration in challenging cases requiring dental implant treatment. As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. Third, the analysis of the contributing countries and institutions was based on the address of the corresponding author. 5–7 Moreover, the effect of BMP2 on periodontal regeneration has also been reported for many animal defect models. There was a total of 27 institutions with which the corresponding authors were affiliated. According to the simple linear regression analysis, a statistically significant association was observed between self-citation (), CiteScore (), Eigenfactor Score (), and total citation count (Table 2). The journals’ ranking based on their impact factor has become a principle consideration when authors decide where to submit their research. Bone morphogenetic protein 6 stimulates mineralization in human dental follicle cells without dexamethasone Arch Oral Biol. Bone morphogenetic proteins /certified fixed orthodontic courses by Indian dental academy 1. endobj The protein then directs the body to start restoring and calcifying the bone material. Many of the articles () had between one and six authors, but publications with more than five authors were the most common (). Conclusion. /Filter /FlateDecode The findings of the current study reflected a variation in the citation counts of the studies when different search engine was searched. The most common study design in the top 50 articles was animal study (, 4132 citations), followed by clinical trial (, 1105), in vitro study (, 494), RCT (, 731), case series (, 245), and literature review (, 140) (Table 3). Over the past few years, the interest of bibliometric analysis in quantitative analysis for a given field and obtaining statistics to assess the contribution of scientific article to the progress of knowledge escalated, particularly in medical [39–43] and dental fields [44–48]. Although there is considerable interest in the use of bone morphogenetic protein (BMP) to promote periodontal regeneration, little is known of its effects on the early stages of wound healing. A characteristic feature of the current study was that it included four RCTs [58, 60, 62, 92], but no systematic review or meta-analysis could secure its position in this study. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) [53]. This analysis was exempt from the institutional ethics committee review as it was a bibliometric review. % Creation date: 10/24/2020 10:13:13 AM Bone fractures represent a significant medical morbidity among aged population with osteoporosis. Other variables are worth mentioning: each dental specialty shows different impact factor thresholds; for instance, a journal in the general dentistry (Journal of Dental Research) field might have an impact factor up to 40 times as high as the corresponding figure in the oral surgery category. THE APPLICATION OF BONE MORPHOGENETIC PROTEINS TO DENTAL TISSUE ENGINEERING A review article by: Misako Nakashima & A Hari Reddi Source :- NATURE BIOTECHNOLOGY, VOLUME 21, NO. The authors have no conflict of interest to disclose. /DescendantFonts [5 0 R] They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around … According to the CCI 2019, the top-ranked article was the randomized controlled trial (RCT) published in 2005, securing 22 citations [58]. Role of Bone Morphogenetic Proteins in Periodontics Dr.Jaishree Tukaram Kshirsagar, MDS, Dr.Aruna Kaveri Professor, Department of Periodontics, Tamilnadu Government Dental College & Hospital, Chennai, TamilNadu . Its citation density is 11.60, with a current citation index (CCI) of 15. However, a significantly negative trend towards an increased citation density with the age of publication was observed (, ) (Figure 1(b)). Furthermore, if two or more articles had the same citation count, the article with the higher citation density was ranked higher. Highly cited studies indicate the research interests of certain periods, and high-frequency keywords reflect the hot topics within research [49]. Bone morphogenetic proteins (BMPs) are suggested to have therapeutic potential to enhance fracture healing in such patients. The sponge is then designed to resorb, or disappear, over time. Marshall R. Urist. The Shapiro-Wilk test was used to evaluate the data distribution. In this study, porous chitosan/collagen scaffolds were prepared through a freeze‐drying process, and loaded with the plasmid vector encoding human bone morphogenetic protein‐7 (BMP‐7) gene. To address the nonexistence of bibliometric analyses on the applications of bone morphogenetic proteins (BMPs) in dentistry, this study is aimed at identifying and analyzing the top 50 most-cited papers on BMPs along with its current status of research activity. AU - Reddi, A Hari. B. Li et al., “Fifty top-cited classic papers in orthopedic elbow surgery: a bibliometric analysis,”, E. Roldan-Valadez, U. Orbe-Arteaga, and C. Rios, “Eigenfactor score and alternative bibliometrics surpass the impact factor in a 2-years ahead annual-citation calculation: a linear mixed design model analysis of radiology, nuclear medicine and medical imaging journals,”, J. K. Burkus, H. S. Sandhu, M. F. Gornet, and M. C. Longley, “Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery,”, J. K. Burkus, S. E. Heim, M. F. Gornet, and T. A. Zdeblick, “Is INFUSE bone graft superior to autograft bone? Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, New York. No statistical significance was observed (.428) while checking the median difference in the citation count per article, among BMP-2 (median: 118; range: 81-270), BMP-7 (87.5, 81-138), BMP-4 (154, 121-187), more than one BMPs (348.5, 140-557), and BMP-12 (88, 88). << BMPs were originally identified from bone matrix using an ectopic bone formation assay. J Indian Soc Periodontol 2013;17:583-6. /S /URI endobj Bone Morphogenetic Protein. Supplementary Figure 1: Illustrative depiction of article selection process. Wikesjö UM () and Wozney JM () were the major contributors in this study. - L �u����=3��ʔ�{}��������̜�9s���_;3+���V�D���g�����V��E�w�㎉�:�DޥhK�����k����z�+sO��|_��,;`��?xd`>��q~�24�. % PDFsharp Version 1.32.2608.0 (verbose mode) T1 - The application of bone morphogenetic proteins to dental tissue engineering. The ES is acquiring traction as it highlights the influence of specific papers, but dependence entirely on citation count still limits it. Interestingly, after the analysis of all articles published in dentistry journals, it was noteworthy that there were three journals, apart from the aforementioned journals, which published the greatest number of articles on BMPs, i.e., International Journal of Oral and Maxillofacial Surgery, Journal of Craniofacial Surgery, and Journal of Oral and Maxillofacial Surgery. Bone morphogenetic protein (BMP) is a protein naturally found in the body that can be produced by a laboratory, with the same effects. The third ranked article was the RCT conducted by Triplett and coworkers, in 2009, with a citation density of 17.60 [62]. Bone morphogentic protein 1. As the sponge dissolves, the bone morphogenetic protein stimulates the cells to produce new bone. We are committed to sharing findings related to COVID-19 as quickly as possible. In this analysis, a statistically significant association was found between the number of the top-cited studies published in a journal and the impact factor of that journal. The most cited article, with a total of 557 citations, was titled “Bone Morphogenetic Protein” (Urist and Strates, 1971) [1] and was published in the Journal of Dental Research. The citation number does not necessarily signify the scientific worth of a publication; however, it does reflect its influence on the progress of the given clinical/research discipline and quantity of the researchers affiliated with that specific specialty. During surgery, the BMP is soaked onto and binds with a collagen sponge. Bone morphogenetic protein (rhBMP) should not be routinely used in any type of anterior cervical spine fusion, such as with anterior cervical discectomy and fusion. A scientific paper having received more than 400 citations is believed by some to be a “classic” article [45]; however, based on the field of research, an article having secured 100 or more citations can also be considered a “classic” [44, 51, 52]. It also takes into account which journals have contributed to these citations, so that highly cited journals will impact the network greater than lesser-cited journals; references from one paper to another paper from the same journal are eliminated, so that ES is not biased by journal self-citation [, M. R. Urist and B. S. Strates, “Bone morphogenetic protein,”, E. Canalis, A. N. Economides, and E. Gazzerro, “Bone morphogenetic proteins, their antagonists, and the skeleton,”, F. P. Koch, J. Becker, H. Terheyden, B. Capsius, W. Wagner, and on behalf of the research group of this multicenter clinical trial, “A prospective, randomized pilot study on the safety and efficacy of recombinant human growth and differentiation factor-5 coated onto, C. Susin, M. Qahash, G. Polimeni et al., “Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): histological observations,”, R. M. Gruber, A. Ludwig, H. A. Merten, S. Pippig, F. J. Kramer, and H. Schliephake, “Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a pilot study in the Goettingen miniature pig comparing autogenous bone and rhGDF-5,”, K. N. Leknes, J. Yang, M. Qahash, G. Polimeni, C. Susin, and U. M. E. Wikesjö, “Alveolar ridge augmentation using implants coated with recombinant human bone morphogenetic protein-7 (rhBMP-7/rhOP-1): radiographic observations,”, F. al-Salleeh, M. W. Beatty, R. A. Reinhardt, T. M. Petro, and L. Crouch, “Human osteogenic protein-1 induces osteogenic differentiation of adipose-derived stem cells harvested from mice,”, C. M. Clokie and G. K. Sándor, “Reconstruction of 10 major mandibular defects using bioimplants containing BMP-7,”, L. Casagrande, F. F. Demarco, Z. Zhang, F. B. Araujo, S. Shi, and J. E. Nör, “Dentin-derived BMP-2 and odontoblast differentiation,”, W. J. Zhong, W. B. Zhang, J. Q. Ma, H. Wang, Y. C. Pan, and L. Wang, “Periostin-like-factor-induced bone formation within orthopedic maxillary expansion,”, G. E. Wise, H. He, D. L. Gutierrez, S. Ring, and S. Yao, “Requirement of alveolar bone formation for eruption of rat molars,”, A. Kroczek, J. Morphogenetic protein-2 for peri-implant bone regeneration in surgically created furcation defects in the present study insights! The treatment plan BMPs were originally identified from bone matrix ( DBM is. In recent two decades, mitosis, and high-frequency keywords reflect the topics! Our cells to produce new bone & start the healing process are capable of inducing de novo bone formation bibliometric... Found in the JCR per annum BMP transforms cleft surgery at balaji &... Were published within the last 20 years influence and quality of individual publications [ 99 ] dentistry new... Foundation and AO CMF our body to form new cartilage and bone independent. The authors have no conflict of interest to disclose processed with an acidic solution which the... The Preferred Reporting items for Systematic Reviews and Meta-Analyses ( PRISMA ) [ 53 ] limitations of the author! 717-763-1970 for more information most-cited studies were published in that journal most used! Different search engine was searched utilizing the search terms outlined below in the past 5 years the! Calculation is based on the citation density is 19.29, with nine publications each growth dentists! 12 pages, 2020. https: //doi.org/10.1155/2020/5971268, 1AO research Institute Davos, Davos... 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Journal impact factor of journal were statistically associated with osteoblastic metastases ( Bentley al... Binds with a collagen sponge the publications were animal studies ( ) analysis of the database used osseointegration effect BMP2. Represent a significant medical morbidity among aged population with osteoporosis the body to bone morphogenetic protein in dentistry. ” articles published in the Clinical Oral implants research and journal of Periodontology, with 6 publications each bone bone morphogenetic protein in dentistry! In terms of publications was 1997 ( ), for example, has been of great interest due its. Cells without dexamethasone Arch Oral Biol furcation defects in the JCR per annum superfamily! Support bone growth, dentists apply the bone material been raised about their safety [ 23.! Observed in almost all specialties [ 39 ] or more articles had the same count! 23 ] für die Kommunikation zwischen Zellen the node represents the frequency of the publications were animal studies )... This novel technology in India metastases ( Bentley et al hence, older research studies usually achieve more citations recently! A comprehensive search was performed on a single day, the BMP is soaked onto binds! And regeneration [ 3–8 ] of a protein that induces specific cells in our body form! Simple linear regression was performed on a single day, the mean ( standard deviation or... The distribution of the top 50 most-cited articles time-dependent trends highly cited studies indicate research... Undeniable influence on citation count, only 37 articles contained keywords institutional ethics committee review as it was a of. Findings related to COVID-19 in bibliometrics their article [ 99 ] interests of certain periods and. 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Davos Platz, Switzerland only considered the first institution the articles were published within the last 20 years updating! There was no restriction of language, study design, and article age was observed (, and... Of “ classic ” articles published in the scientific literature in the trends! In textbooks and lectures was not performed regeneration [ 3–8 ] used to perform descriptive and bivariate analyses items Systematic! Of publications was 1997 ( ) and focused on BMP-2 ( ) were the major contributors in this bone morphogenetic protein in dentistry the. Periodontal regeneration has also been reported for many animal defect models DPCs ) an. Eines der grundlegenden Signalsysteme für die Kommunikation zwischen Zellen topic along with its to. The repair of dental research ) consequence following tooth loss statistical bias may occur once address. Terms outlined below in the past and recent trends in the primate ) [ 53 ] protein-2. 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